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Details for messenger / hormone: semaphorin 3A

EndoNet ID: ENH00535

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Synonyms

  • SEMA3A
  • collapsin 1
  • SemD
  • semaphorin III
  • sema III
  • sema 3
  • semaphorin 3
  • Sema3A
  • coll-1
  • Hsema-I
  • SEMA1
  • SEMAD
  • SEMAIII
  • SEMAL
  • proSemD
  • sema domain immunoglobulin domain short basic domain secreted 3A
  • sema domain Ig domain short basic domain secreted 3A
  • semaphorin L
  • semaphorin-like
  • semaphorin 3A
  • semaphorin D
  • semaphorin-3A

General information

  • Semaphorin III (Sema III) is a secreted protein that in vitro causes neuronal growth cone collapse and chemorepulsion of neurites, and in vivo is required for correct sensory afferent innervation and other aspects of development. [1]
  • Sema 3A signaling regulates the expression and interactions of slit-diaphragm proteins and decreases podocyte survival. [2]
  • Vascular EC-derived sema 3s inhibit sympathetic axon growth and may thus be a determinant of vascular sympathetic innervation. [3]
  • Induces the collapse and paralysis of neuronal growth cones. [4]

Classification

Hormone function

  • development and growth
    • growth inhibition

    Chemical classification

    • hormone
      • genome-encoded

    Composition

    Semaphorin-3A

    Sequence 
    NYQNGKNNV PRLKLSYKE MLESNNVIT 
FNGLANSSS YHTFLLDEE RSRLYVGAK 
DHIFSFDLV NIKDFQKIV WPVSYTRRD 
ECKWAGKDI LKECANFIK VLKAYNQTH 
LYACGTGAF HPICTYIEI GHHPEDNIF 
KLENSHFEN GRGKSPYDP KLLTASLLI 
DGELYSGTA ADFMGRDFA IFRTLGHHH 
PIRTEQHDS RWLNDPKFI SAHLISESD 
NPEDDKVYF FFRENAIDG EHSGKATHA 
RIGQICKND FGGHRSLVN KWTTFLKAR 
LICSVPGPN GIDTHFDEL QDVFLMNFK 
DPKNPVVYG VFTTSSNIF KGSAVCMYS 
MSDVRRVFL GPYAHRDGP NYQWVPYQG 
RVPYPRPGT CPSKTFGGF DSTKDLPDD 
VITFARSHP AMYNPVFPM NNRPIVIKT 
DVNYQFTQI VVDRVDAED GQYDVMFIG 
TDVGTVLKV VSIPKETWY DLEEVLLEE 
MTVFREPTA ISAMELSTK QQQLYIGST 
AGVAQLPLH RCDIYGKAC AECCLARDP 
YCAWDGSAC SRYFPTAKR RTRRQDIRN 
GDPLTHCSD LHHDNHHGH SPEERIIYG 
VENSSTFLE CSPKSQRAL VYWQFQRRN 
EERKEEIRV DDHIIRTDQ GLLLRSLQQ 
KDSGNYLCH AVEHGFIQT LLKVTLEVI 
DTEHLEELL HKDDDGDGS KTKEMSNSM 
TPSQKVWYR DFMQLINHP NLNTMDEFC 
EQVWKRDRK QRRQRPGHT PGNSNKWKH 
LQENKKGRN RRTHEFERA PRSV
    UniProt Q14563

    Links to other resources

    UniProt Q14563
    Ensembl ENST00000436949
    KEGG hsa:10371

    • Anatomical structure: podocyte

      • Semaphorins 3A (sema 3A) and 3F are expressed by podocytes in vivo throughout ontogeny. [2]

    Targets

    Cellneuropilin 1PLXNA1PLXNA2PLXNA3PLXNA4
    blood vessel Present
    Phenotypes
    • excess of capillary formation
    • patterning of blood vessels
    bone marrow Present
    brain Present
    Phenotypes
    • axon guidance
    		Present
    glomerulus Present
    Phenotypes
    • induction of podocyte apoptosis
    • formation of glomerular filter barrier
    • inhibition of glomerular capillary lumen development
    • patterning of blood vessels
    • positive regulation of apoptosis
    heart Present
    Phenotypes
    • patterning of blood vessels
    kidney Present
    Phenotypes
    • inhibition of ureteric bud branching
    • excess of endothelial cells
    • podocyte differentiation
    • cell differentiation
    • acute nephrotic range proteinuria
    lung Present
    mammary gland Present
    pancreas Present
    placenta Present
    		Present
    podocyte Present
    skeleton muscle Present
    		Present
    Reference