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Details for messenger / hormone: slit-2 isoform 1 N-product

EndoNet ID: ENH00978

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Synonyms

  • slit-2 isoform 1 N-product
  • slit homolog 2 protein isoform 1 N-product
  • SLIT2 isoform 1 N-product
  • SLIL3 isoform 1 N-product
  • neurogenic extracellular slit
  • slit2-N
  • slit homolog 2 protein

General information

  • The neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. [1]
  • Slit2 is a repellent for retinal ganglion cell axons. [2]
  • Promoter region hypermethylation and transcriptional silencing of SLIT2 in lung, breast, colorectal and glioma cell lines and primary tumours have been reported. [3]
  • Slit2 is cleaved into Slit2-N, a protein tightly binding to cell membranes, and Slit2-C, a diffusible fragment. [1]
  • On binding to Robo receptors, Slit2 repels developing axons and inhibits leukocyte chemotaxis. [1]
  • SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. [4]
  • Heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction. [5]
  • Re-expression of SLIT2 inhibits the growth of cancer cell lines so that SLIT2 appears to function as a novel tumour suppressor gene. [3]
  • Slit2, a neuronal repellent factor, is up-regulated in the skin by allergen sensitization and down-regulates the migration of Langerhans cells. [6]
  • Slit2 can act bifunctionally, both repulsing and stimulating the motility of trunk neural crest cells. [7]
  • EphrinA5 and slit2 are important repulsive guidance cues in the developing retinotectal system. [8]

Classification

Hormone function

  • development and growth
    • cancer / metastasis
      • growth inhibition

      Chemical classification

      Composition

      Slit homolog 2 protein isoform 1 N-product.

      • SLIT2 gene at 4p15.31. [9]
      Sequence 
      QCSCSGSTV DCHGLALRS VPRNIPRNT 
ERLDLNGNN ITRITKTDF AGLRHLRVL 
QLMENKIST IERGAFQDL KELERLRLN 
RNHLQLFPE LLFLGTAKL YRLDLSENQ 
IQAIPRKAF RGAVDIKNL QLDYNQISC 
IEDGAFRAL RDLEVLTLN NNNITRLSV 
ASFNHMPKL RTFRLHSNN LYCDCHLAW 
LSDWLRQRP RVGLYTQCM GPSHLRGHN 
VAEVQKREF VCSGHQSFM APSCSVLHC 
PAACTCSNN IVDCRGKGL TEIPTNLPE 
TITEIRLEQ NTIKVIPPG AFSPYKKLR 
RIDLSNNQI SELAPDAFQ GLRSLNSLV 
LYGNKITEL PKSLFEGLF SLQLLLLNA 
NKINCLRVD AFQDLHNLN LLSLYDNKL 
QTIAKGTFS PLRAIQTMH LAQNPFICD 
CHLKWLADY LHTNPIETS GARCTSPRR 
LANKRIGQI KSKKFRCSA KEQYFIPGT 
EDYRSKLSG DCFADLACP EKCRCEGTT 
VDCSNQKLN KIPEHIPQY TAELRLNNN 
EFTVLEATG IFKKLPQLR KINFSNNKI 
TDIEEGAFE GASGVNEIL LTSNRLENV 
QHKMFKGLE SLKTLMLRS NRITCVGND 
SFIGLSSVR LLSLYDNQI TTVAPGAFD 
TLHSLSTLN LLANPFNCN CYLAWLGEW 
LRKKRIVTG NPRCQKPYF LKEIPIQDV 
AIQDFTCDD GNDDNSCSP LSRCPTECT 
CLDTVVRCS NKGLKVLPK GIPRDVTEL 
YLDGNQFTL VPKELSNYK HLTLIDLSN 
NRISTLSNQ SFSNMTQLL TLILSYNRL 
RCIPPRTFD GLKSLRLLS LHGNDISVV 
PEGAFNDLS ALSHLAIGA NPLYCDCNM 
QWLSDWVKS EYKEPGIAR CAGPGEMAD 
KLLLTTPSK KFTCQGPVD VNILAKCNP 
CLSNPCKND GTCNSDPVD FYRCTCPYG 
FKGQDCDVP IHACISNPC KHGGTCHLK 
EGEEDGFWC ICADGFEGE NCEVNVDDC 
EDNDCENNS TCVDGINNY TCLCPPEYT 
GELCEEKLD FCAQDLNPC QHDSKCILT 
PKGFKCDCT PGYVGEHCD IDFDDCQDN 
KCKNGAHCT DAVNGYTCI CPEGYSGLF 
CEFSPPMVL PR
      UniProt O94813

      Links to other resources

      UniProt O94813
      Ensembl ENST00000273739
      KEGG hsa:9353

      • Anatomical structure: artery

      • Anatomical structure: glomerulus

      • Anatomical structure: distal_tubule_of_nephron

      • Anatomical structure: spinal_cord

      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: glial_cell_of_central_nervous_system

      • Anatomical structure: retina

      Targets

      Cellglypican 1syndecan
      bone marrow Present
      brain Present
      breast Present
      mammary gland Present
      ovary Present
      propria mucosa of bronchus Present
      skeleton muscle Present
      Reference