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Details for messenger / hormone: Syntaxin-4

EndoNet ID: ENH01128

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  • renal carcinoma antigen NY-REN-31
  • Syntaxin-4
  • STX4

General information

  • Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. May also play a role in docking of synaptic vesicles at presynaptic active zones.
  • Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.
  • Syntaxin 4 plays a role in glucosestimulated insulin secretion and that this process may be negatively regulated by the syntaxin 4-interacting protein Synip. [1]


Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone

    Links to other resources

    UniProt Q12846
    Ensembl ENST00000313843
    KEGG hsa:6810
    • Anatomical structure: neutrophil_granulocyte

      • Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.
    • Anatomical structure: pancreas


    No records found.