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Details for receptor: uPAR1

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EndoNet ID: ENR00279

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Synonyms

  • uPAR1
  • urokinase receptor
  • urokinase plasminogen activator surface receptor
  • U-PAR
  • monocyte activation antigen Mo3
  • CD87 antigen
  • PLAUR
  • uPAR1, GPI-anchored

General information

  • Integrin ligand. [1]
  • The D1 domain of uPAR is required for the association of uPAR with integrin, and signaling. [1]
  • uPAR-Mac-1 (CD11b/CD18) interaction. [1]
  • Association of uPAR with alphaV-beta5 integrin. [1]
  • The serine protease urokinase (uPA) binds to the urokinase receptor through its growth-factor domain, affecting cell migration, adhesion and growth. [1]
  • The uPAR ability to modify integrin activity as well as integrin-dependent signaling implies that it is a cis-acting integrin regulator. [1]

Links to other resources

UniProt Q03405-1
Ensembl ENST00000340093

Subunit information

uPAR1

  • GPI-anchored. [2]
Sequence 
LRCMQCKTN GDCRVEECA LGQDLCRTT 
IVRLWEEGE ELELVEKSC THSEKTNRT 
LSYRTGLKI TSLTEVVCG LDLCNQGNS 
GRAVTYSRS RYLECISCG SSDMSCERG 
RHQSLQCRS PEEQCLDVV THWIQEGEE 
GRPKDDRHL RGCGYLPGC PGSNGFHNN 
DTFHFLKCC NTTKCNEGP ILELENLPQ 
NGRQCYSCK GNSTHGCSS EETFLIDCR 
GPMNQCLVA TGTHEPKNQ SYMVRGCAT 
ASMCQHAHL GDAFSMNHI DVSCCTKSG 
CNHPDLDVQ YRSG
UniProt Q03405-1

Binding hormones

  • urokinase-type plasminogen activator

Anatomical structures with this receptor

    Reference