Status
Please wait ...

Details for messenger / hormone: urokinase-type plasminogen activator

EndoNet ID: ENH00943

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • urokinase-type plasminogen activator
  • U-plasminogen activator
  • uPA
  • PLAU

General information

  • Function: uPA coordinates ECM proteolysis and cell signalling for cell migration, proliferation, inflammation and survival. [1]

Classification

Hormone function

  • development and growth
    • apoptosis
      • environment adaptation
      • metabolism
        • cell metabolism

        Chemical classification

        • hormone
          • genome-encoded
            • peptidase S1 family

          Composition

          Urokinase-type plasminogen activator long chain A

          Sequence 
          SNELHQVPS NCDCLNGGT CVSNKYFSN 
IHWCNCPKK FGGQHCEID KSKTCYEGN 
GHFYRGKAS TDTMGRPCL PWNSATVLQ 
QTYHAHRSD ALQLGLGKH NYCRNPDNR 
RRPWCYVQV GLKPLVQEC MVHDCADGK 
KPSSPPEEL KFQCGQKTL RPRF

          Urokinase-type plasminogen activator short chain A

          Sequence 
          KPSSPPEEL KFQCGQKTL RPRF

          Urokinase-type plasminogen activator chain B

          Sequence 
          IIGGEFTTI ENQPWFAAI YRRHRGGSV 
TYVCGGSLM SPCWVISAT HCFIDYPKK 
EDYIVYLGR SRLNSNTQG EMKFEVENL 
ILHKDYSAD TLAHHNDIA LLKIRSKEG 
RCAQPSRTI QTICLPSMY NDPQFGTSC 
EITGFGKEN STDYLYPEQ LKMTVVKLI 
SHRECQQPH YYGSEVTTK MLCAADPQW 
KTDSCQGDS GGPLVCSLQ GRMTLTGIV 
SWGRGCALK DKPGVYTRV SHFLPWIRS 
HTKEENGLA L

          Links to other resources

          UniProt P00749
          Ensembl ENST00000372764
          KEGG hsa:5328

          • Anatomical structure: prostate

          Targets

          CellMRC2uPAR1
          brain Present
          colon Present
          continuous vascular endothelial cell of blood vessels and lymphatics Present
          fibroblast Present
          kidney Present
          lung Present
          macrophage Present
          pancreas Present
          placenta Present
          spleen Present
          thymus Present
          Reference