Details for anatomical structure: basophil gonadotroph cell of anterior pituitary FSH

Related structures
Hormones
Receptors
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EndoNet ID: ENC00003

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Synonyms

basophil gonadotroph cell of anterior pituitary FSH, chromophil cell, Endocrinocytus basophilus

General information

secreting follicle-stimulating hormone

Links to other resources

Cytomer

cy0011194

Larger structures

Substructures

Secreted hormones

Hormone: LH
Influenced by:
- gonadotropin-releasing hormone receptor
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Correlation between the GnRH-stimulated release of both LH and SgII in vitro. [1]
  Co-localization and co-release of LH and SgII in vivo. [2]
  SgII plays an important role in the regulated secretion of LH. [3]
  Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
  LH released in response to GnRH is co-released with SgII via a regulated secretory pathway and that the activinstimulated LH release is probably via a constitutive, SgII-granule-independent pathway. [3]
- unspecified testosterone receptor 2
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Feedback inhibition of testosterone on the synthesis and secretion of LH from the pituitary. [4]
- ER-alpha
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Action of estradiol is dependent upon its concentration. It can either in- or decrease the cells' responsiveness to GnRH. [5]
- CXCR1
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  CINC/gro suppresses rapid the basal LH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
- ACTRIIA
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Activin had a stimulatory effect on LH secretion, although this response was not dose dependent. [3]
  Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
- unspecified progesterone receptor
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Short exposure to physiological levels of progesterone in the range of early luteal phase levels has a stimulatory effect on LH secretion by acting directly at the pituitary level. [7]
- NPFF-R1
  in pituitary_gland_of_diencephalon
  Thus, GnIH/RFRP may inhibit gonadotropin synthesis and release by direct actions on the pituitary gland. [8]
Hormone: angiotensin II
- [9]
Hormone: TRH
- [9]
Hormone: VIP
- [9]
Hormone: FST
Hormone: FSH
Influenced by:
- CXCR1
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  CINC/gro suppresses rapid the basal FSH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
- ER-alpha:ER-beta
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Regulation of FSH release is through negative feedback of gonadal steroids, particularly estradiol, which act directly at the pituitary.
- unspecified testosterone receptor 1
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Regulation of FSH release is through negative feedback of gonadal steroids, particularly testosterone, which act directly at the pituitary. [3]
- ACTRIIA
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  While FSH secretion in LbetaT2 cells was stimulated, in a dose-dependent manner, by activin alone, and was unaffected by GnRH alone, there was a synergistic effect between the two treatments. [3]
  FSH produced in LbetaT2 cells under activin/GnRH stimulation is constitutively secreted via a granin-independent pathway. [3]
- gonadotropin-releasing hormone receptor
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  GnRH requires the presence of activin in order to exert its action. [3]
- NPFF-R1
  in pituitary_gland_of_diencephalon
  Thus, GnIH/RFRP may inhibit gonadotropin synthesis and release by direct actions on the pituitary gland. [8]
Hormone: secretogranin-2
Influenced by:
- gonadotropin-releasing hormone receptor
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Co-localization and co-release of LH and SgII in vivo. [2]
  Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
Hormone: secretoneurin
Influenced by:
- gonadotropin-releasing hormone receptor
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  Co-localization and co-release of LH and SgII in vivo. [2]
  Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
Hormone: chromogranin A
Influenced by:
- gonadotropin-releasing hormone receptor
  in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
  CgA secretion was maintained by GnRH and reduced below control levels by transfer to activin only. [3]

Receptors

Receptor: gonadotropin-releasing hormone receptor
Induced phenotype:
- hypogonadotropic hypogonadism
  
  Hypogonadotropic hypogonadism can be caused by mutations in multiple genes, including the gonadotropin-releasing hormone receptor gene. [10]
Influences:
- LH
  
  Correlation between the GnRH-stimulated release of both LH and SgII in vitro. [1]
  Co-localization and co-release of LH and SgII in vivo. [2]
  SgII plays an important role in the regulated secretion of LH. [3]
  Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
  LH released in response to GnRH is co-released with SgII via a regulated secretory pathway and that the activinstimulated LH release is probably via a constitutive, SgII-granule-independent pathway. [3]
- FSH
- secretoneurin
  
  Co-localization and co-release of LH and SgII in vivo. [2]
  Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
- secretogranin-2
  
  Co-localization and co-release of LH and SgII in vivo. [2]
  Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
- FSH
  
  GnRH requires the presence of activin in order to exert its action. [3]
- chromogranin A
  
  CgA secretion was maintained by GnRH and reduced below control levels by transfer to activin only. [3]
Receptor: unspecified testosterone receptor 2
Influences:
- LH
  
  Feedback inhibition of testosterone on the synthesis and secretion of LH from the pituitary. [4]
Receptor: ACTRIIA
Influences:
- FSH
  
  While FSH secretion in LbetaT2 cells was stimulated, in a dose-dependent manner, by activin alone, and was unaffected by GnRH alone, there was a synergistic effect between the two treatments. [3]
  FSH produced in LbetaT2 cells under activin/GnRH stimulation is constitutively secreted via a granin-independent pathway. [3]
- LH
  
  Activin had a stimulatory effect on LH secretion, although this response was not dose dependent. [3]
  Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
Receptor: ER-alpha
Influences:
- FSH
  
  The action of estradiol is dependent upon its concentration. It can either increase or decrease the responsiveness to GnRH. [5]
- LH
  
  Action of estradiol is dependent upon its concentration. It can either in- or decrease the cells' responsiveness to GnRH. [5]
Receptor: unspecified progesterone receptor
Influences:
- LH
  
  Short exposure to physiological levels of progesterone in the range of early luteal phase levels has a stimulatory effect on LH secretion by acting directly at the pituitary level. [7]
Receptor: CXCR1
Influences:
- FSH
  
  CINC/gro suppresses rapid the basal FSH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
- LH
  
  CINC/gro suppresses rapid the basal LH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
Receptor: ER-alpha:ER-beta
Influences:
- FSH
  
  Regulation of FSH release is through negative feedback of gonadal steroids, particularly estradiol, which act directly at the pituitary.
Receptor: unspecified testosterone receptor 1
Influences:
- FSH
  
  Regulation of FSH release is through negative feedback of gonadal steroids, particularly testosterone, which act directly at the pituitary. [3]

Reference

EndoNet

The information resource about the endocrine network in human.

Details for anatomical structure: basophil gonadotroph cell of anterior pituitary FSH

Synonyms

General information

Links to other resources

Related structures

Larger structures

Substructures

Secreted hormones

Hormone: LH ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_0_toolsBtn',{id:'j_idt91:0:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_0_j_idt99',{id:'j_idt91:0:j_idt99',target:'j_idt91:0:toolsBtn',dynamic:true});});

Influenced by:

Hormone: angiotensin II ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_1_toolsBtn',{id:'j_idt91:1:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_1_j_idt99',{id:'j_idt91:1:j_idt99',target:'j_idt91:1:toolsBtn',dynamic:true});});

Hormone: TRH ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_2_toolsBtn',{id:'j_idt91:2:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_2_j_idt99',{id:'j_idt91:2:j_idt99',target:'j_idt91:2:toolsBtn',dynamic:true});});

Hormone: VIP ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_3_toolsBtn',{id:'j_idt91:3:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_3_j_idt99',{id:'j_idt91:3:j_idt99',target:'j_idt91:3:toolsBtn',dynamic:true});});

Hormone: FST ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_4_toolsBtn',{id:'j_idt91:4:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_4_j_idt99',{id:'j_idt91:4:j_idt99',target:'j_idt91:4:toolsBtn',dynamic:true});});

Hormone: FSH ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_5_toolsBtn',{id:'j_idt91:5:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_5_j_idt99',{id:'j_idt91:5:j_idt99',target:'j_idt91:5:toolsBtn',dynamic:true});});

Influenced by:

Hormone: secretogranin-2 ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_6_toolsBtn',{id:'j_idt91:6:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_6_j_idt99',{id:'j_idt91:6:j_idt99',target:'j_idt91:6:toolsBtn',dynamic:true});});

Influenced by:

Hormone: secretoneurin ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_7_toolsBtn',{id:'j_idt91:7:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_7_j_idt99',{id:'j_idt91:7:j_idt99',target:'j_idt91:7:toolsBtn',dynamic:true});});

Influenced by:

Hormone: chromogranin A ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt91_8_toolsBtn',{id:'j_idt91:8:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt91_8_j_idt99',{id:'j_idt91:8:j_idt99',target:'j_idt91:8:toolsBtn',dynamic:true});});

Influenced by:

Receptors

Receptor: gonadotropin-releasing hormone receptor ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_0_toolsBtn',{id:'j_idt139:0:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_0_j_idt145',{id:'j_idt139:0:j_idt145',target:'j_idt139:0:toolsBtn',dynamic:true});});

Induced phenotype:

Influences:

Receptor: unspecified testosterone receptor 2 ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_1_toolsBtn',{id:'j_idt139:1:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_1_j_idt145',{id:'j_idt139:1:j_idt145',target:'j_idt139:1:toolsBtn',dynamic:true});});

Influences:

Receptor: ACTRIIA ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_2_toolsBtn',{id:'j_idt139:2:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_2_j_idt145',{id:'j_idt139:2:j_idt145',target:'j_idt139:2:toolsBtn',dynamic:true});});

Influences:

Receptor: ER-alpha ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_3_toolsBtn',{id:'j_idt139:3:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_3_j_idt145',{id:'j_idt139:3:j_idt145',target:'j_idt139:3:toolsBtn',dynamic:true});});

Influences:

Receptor: unspecified progesterone receptor ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_4_toolsBtn',{id:'j_idt139:4:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_4_j_idt145',{id:'j_idt139:4:j_idt145',target:'j_idt139:4:toolsBtn',dynamic:true});});

Influences:

Receptor: CXCR1 ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_5_toolsBtn',{id:'j_idt139:5:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_5_j_idt145',{id:'j_idt139:5:j_idt145',target:'j_idt139:5:toolsBtn',dynamic:true});});

Influences:

Receptor: ER-alpha:ER-beta ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_6_toolsBtn',{id:'j_idt139:6:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_6_j_idt145',{id:'j_idt139:6:j_idt145',target:'j_idt139:6:toolsBtn',dynamic:true});});

Influences:

Receptor: unspecified testosterone receptor 1 ui-buttonPrimeFaces.cw('CommandButton','widget_j_idt139_7_toolsBtn',{id:'j_idt139:7:toolsBtn'}); $(function(){PrimeFaces.cw('OverlayPanel','widget_j_idt139_7_j_idt145',{id:'j_idt139:7:j_idt145',target:'j_idt139:7:toolsBtn',dynamic:true});});

Influences:

Hormone: LH

Hormone: angiotensin II

Hormone: TRH

Hormone: VIP

Hormone: FST

Hormone: FSH

Hormone: secretogranin-2

Hormone: secretoneurin

Hormone: chromogranin A

Receptor: gonadotropin-releasing hormone receptor

Receptor: unspecified testosterone receptor 2

Receptor: ACTRIIA

Receptor: ER-alpha

Receptor: unspecified progesterone receptor

Receptor: CXCR1

Receptor: ER-alpha:ER-beta

Receptor: unspecified testosterone receptor 1