Please wait ...

Details for messenger / hormone: bradykinin

EndoNet ID: ENH00062

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • bradykinin
  • kallidin 9
  • kallidin I
  • BK

General information

  • The pro-inflammatory effects of bradykinin is mediated by at least two receptors: B2 and B1. The B2 subtype is expressed constitutively and the B1 receptor is induced following tissue inflammation and damage. The endogenous ligand for the B1 receptor is des-arg9BK, a cleavage product of the activity of carboxypeptidase on BK. Activation of B1 receptors produces a range of pro-inflammatory effects including oedema, pain and promotion of blood-borne leukocyte trafficking. [1]
  • Bradykinin and its biologically active metabolite des-Arg9 bradykinin (DABK), are produced at sites of inflammation and are important inflammatory mediators. [2]
  • Bradykinin is a 9 amino acid peptide chain. It is processed from a kininogen precursor by kallikreins.
  • Bradykinin stimulates vasodilatation and endothelial cell proliferation. [3]


Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded
        • kinins


      isoform HMW

      UniProt P01042-1
      KEGG C00306

      Links to other resources

      UniProt P01042
      Ensembl ENST00000447445
      KEGG hsa:3827
      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: blood_vessel


      Cellbradykinin receptor B1bradykinin receptor B2
      endothelial cell Present
      neutrophil granulocyte Present
      • Neutrophil chemotaxis
      osteoblast Present
      • PGE2
      • PGI2
      • interleukin 6
      • PGE2
      • PGI2