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Details for messenger / hormone: Wnt-1

EndoNet ID: ENH00477

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Synonyms

  • proto-oncogene Int-1 homolog
  • proto-oncogene Wnt-1
  • Wnt-1
  • INT1
  • WNT-1 proto-oncogene protein
  • WNT1
  • wingless-type MMTV integration site family member 1

General information

  • Optimal Wnt signaling also requires association with glycosaminoglycans (e.g. heparin sulfate and chondroitin sulfate) in the extracellular matrix. [1]
  • Wnt-1 plays an important role in the disturbed differentiation and uncontrolled proliferation during oral squamous cell carcinoma carcinogenesis. [2]
  • Wnt proteins are lipid-modified and can act as stem cell growth factors. [3]
  • Member of the Wnt1 class (inducers of secondary body axis in Xenopus), which facilitates Fzd and Lrp interactions and activates the canonical Wnt/beta-catenin pathway. [1]
  • All Wnts contain 23-24 cysteine residues. [1]
  • Wnt1 and Wnt10b prevented adipogenesis of preadipocyte cells. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • Wnt family

      Composition

      Sequence 
      ANSSGRWWG IVNVASSTN LLTDSKSLQ 
LVLEPSLQL LSRKQRRLI RQNPGILHS 
VSGGLQSAV RECKWQFRN RRWNCPTAP 
GPHLFGKIV NRGCRETAF IFAITSAGV 
THSVARSCS EGSIESCTC DYRRRGPGG 
PDWHWGGCS DNIDFGRLF GREFVDSGE 
KGRDLRFLM NLHNNEAGR TTVFSEMRQ 
ECKCHGMSG SCTVRTCWM RLPTLRAVG 
DVLRDRFDG ASRVLYGNR GSNRASRAE 
LLRLEPEDP AHKPPSPHD LVYFEKSPN 
FCTYSGRLG TAGTAGRAC NSSSPALDG 
CELLCCGRG HRTRTQRVT ERCNCTFHW 
CCHVSCRNC THTRVLHEC L

      Links to other resources

      UniProt P04628
      Ensembl ENST00000293549
      KEGG hsa:7471

      • Anatomical structure: osteoblast

      Targets

      Cellfrizzled 1
      heart Present
      kidney Present
      lung Present
      ovary Present
      pancreas Present
      pancreatic islets Present
      placenta Present
      prostate Present
      thyroid gland Present
      Reference