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Details for messenger / hormone: WNT7A

EndoNet ID: ENH00486

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Synonyms

  • WNT7A
  • protein Wnt-7a

General information

  • All Wnts contain 23-24 cysteine residues. [1]
  • Member of the Wnt5a class (cannot induce secondary body axis formation in Xenopus), which binds Fzd to activate heterotrimeric G proteins and increase intracellular calcium levels or induce Rho-dependent changes in the actin cytoskeleton. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis
    • reproduction and sexual differentiation
      • sexual differentiation

      Chemical classification

      • hormone
        • genome-encoded
          • Wnt family

        Composition

        Sequence 
        LGATIICNK IPGLAPRQR AICQSRPDA 
IIVIGEGSQ MGLDECQFQ FRNGRWNCS 
ALGERTVFG KELKVGSRD GAFTYAIIA 
AGVAHAITA ACTHGNLSD CGCDKEKQG 
QYHRDEGWK WGGCSADIR YGIGFAKVF 
VDAREIKQN ARTLMNLHN NEAGRKILE 
ENMKLECKC HGVSGSCTT KTCWTTLPQ 
FRELGYVLK DKYNEAVHV EPVRASRNK 
RPTFLKIKK PLSYRKPMD TDLVYIEKS 
PNYCEEDPV TGSVGTQGR ACNKTAPQA 
SGCDLMCCG RGYNTHQYA RVWQCNCKF 
HWCCYVKCN TCSERTEMY TCK

        Links to other resources

        UniProt O00755
        Ensembl ENST00000285018
        KEGG hsa:7476

          Targets

          Cellfrizzled 10frizzled 9
          adrenal medulla Present
          brain Present
          		Present
          cerebellar cortex Present
          cerebellum Present
          eye Present
          heart Present
          hippocampus Present
          kidney Present
          left coronary artery Present
          pancreas Present
          placenta Present
          putamen Present
          right coronary artery Present
          skeleton muscle Present
          		Present
          spinal cord Present
          spleen Present
          substantia nigra Present
          testis Present
          Reference